Empirical Parameters for Estimating Protein-Protein Binding Energies: Number of Short- and Long-Distance Atom-Atom Contacts

Title: Empirical Parameters for Estimating Protein-Protein Binding Energies: Number of Short- and Long-Distance Atom-Atom Contacts

Volume: 15 Issue: 2

Author(s): Zong-Hao Zeng, Yong Chao Li and Yong Chao Li

Affiliation:

Abstract: The number of atom-atom contacts in long distance can fit to the experimental binding energies in a dataset containing 151 experimental data with the correlation coefficient about 0.68. Based on this factor, a set of distancedependent empirical potentials for various types of short-distance (2.4 Å -5 Å ) contacts was obtained by guided fitting, i.e. a set of two parameters fitting. Incorporation of these short-distance potentials improved the correlation coefficients to 0.881.

Cite this article as:

Zeng Zong-Hao, Li Chao Yong and Chao Li Yong, Empirical Parameters for Estimating Protein-Protein Binding Energies: Number of Short- and Long-Distance Atom-Atom Contacts, Protein & Peptide Letters 2008; 15 (2) . https://dx.doi.org/10.2174/092986608783489634