Immobilization of Heparin: Approaches and Applications

Title: Immobilization of Heparin: Approaches and Applications

Volume: 8 Issue: 2

Author(s): Robert J. Linhardt, Saravanababu Murugesan and Jin Xie

Affiliation:

Keywords: Heparin, Immobilization, Blood compatibility

Abstract: Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.

Cite this article as:

Linhardt J. Robert, Murugesan Saravanababu and Xie Jin, Immobilization of Heparin: Approaches and Applications, Current Topics in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/156802608783378891