Abstract
A convenient and green protocol for the synthesis of quinolines by Friedlander annulation using an acidic ionic liquid, ethylammonium nitrate, as both a catalyst and a reaction medium is reported. The reactions were performed at 45°C with moderate to excellent yields. The recovered ionic liquid could be reused for several cycles without any loss of activity.
Keywords: Ionic liquid, Friedlander reaction, quinoline
Letters in Organic Chemistry
Title: A Convenient Synthesis of Quinolines via Ionic Liquid-Catalysed Friedlander Annulation
Volume: 5 Issue: 1
Author(s): Tao Zhou, Jian-Li Lin and Zhen-Chu Chen
Affiliation:
Keywords: Ionic liquid, Friedlander reaction, quinoline
Abstract: A convenient and green protocol for the synthesis of quinolines by Friedlander annulation using an acidic ionic liquid, ethylammonium nitrate, as both a catalyst and a reaction medium is reported. The reactions were performed at 45°C with moderate to excellent yields. The recovered ionic liquid could be reused for several cycles without any loss of activity.
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Cite this article as:
Zhou Tao, Lin Jian-Li and Chen Zhen-Chu, A Convenient Synthesis of Quinolines via Ionic Liquid-Catalysed Friedlander Annulation, Letters in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157017808783330261
DOI https://dx.doi.org/10.2174/157017808783330261 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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