Zr(OTf)4-Catalyzed Direct Three-Component Mannich-Type Reaction of Carbamates: An Efficient One-Step Synthesis of N-Protected β- Aryl-β -Amino Ketones

Li-Wen      Xu; Lei      Yang; Wei      Sun; Chun-Gu      Xia

doi:10.2174/157017808783330270

Abstract

Carbamates were reacted in one pot with aromatic aldehyde and ketones at ambient temperature in the presence of catalytic amount of Zr(OTf)4 to furnish the corresponding N-protected β-amino-β-aryl ketones in good yields.

Keywords: Aza-Michael reaction, Mannich reaction, Zirconium, one pot, carbamate, amino ketone

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Letters in Organic Chemistry

Title: Zr(OTf)4-Catalyzed Direct Three-Component Mannich-Type Reaction of Carbamates: An Efficient One-Step Synthesis of N-Protected β- Aryl-β -Amino Ketones

Volume: 5 Issue: 1

Author(s): Li-Wen Xu, Lei Yang, Wei Sun and Chun-Gu Xia

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Keywords: Aza-Michael reaction, Mannich reaction, Zirconium, one pot, carbamate, amino ketone

Abstract: Carbamates were reacted in one pot with aromatic aldehyde and ketones at ambient temperature in the presence of catalytic amount of Zr(OTf)4 to furnish the corresponding N-protected β-amino-β-aryl ketones in good yields.

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Xu Li-Wen, Yang Lei, Sun Wei and Xia Chun-Gu, Zr(OTf)4-Catalyzed Direct Three-Component Mannich-Type Reaction of Carbamates: An Efficient One-Step Synthesis of N-Protected β- Aryl-β -Amino Ketones, Letters in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157017808783330270