Copper(I) Bromide Promoted Selective Reduction of N-substituted Phthalimides with Zinc

Lixin      Wang; Jiyu      Wang; Fan      Yang; Jianfeng      Shen; Wen      Wang

doi:10.2174/157017808783330171

Abstract

A new selective reduction of N-substituted phthalimides to the corresponding hydroxyl lactams is described. This reduction performed smoothly under mild, concise and easily controllable condition in good yield (up to 97%). The generality of the reduction was also investigated and a wide range of substrates were suitable for this reaction.

Keywords: Phthalimide, hydroxyphalimidines, zinc, copper (I) bromide, reduction

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Letters in Organic Chemistry

Title: Copper(I) Bromide Promoted Selective Reduction of N-substituted Phthalimides with Zinc

Volume: 5 Issue: 1

Author(s): Lixin Wang, Jiyu Wang, Fan Yang, Jianfeng Shen and Wen Wang

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Keywords: Phthalimide, hydroxyphalimidines, zinc, copper (I) bromide, reduction

Abstract: A new selective reduction of N-substituted phthalimides to the corresponding hydroxyl lactams is described. This reduction performed smoothly under mild, concise and easily controllable condition in good yield (up to 97%). The generality of the reduction was also investigated and a wide range of substrates were suitable for this reaction.

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Wang Lixin, Wang Jiyu, Yang Fan, Shen Jianfeng and Wang Wen, Copper(I) Bromide Promoted Selective Reduction of N-substituted Phthalimides with Zinc, Letters in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157017808783330171