Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1)

Title: Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1)

Volume: 1 Issue: 4

Author(s): D. Barlocco, L. Toma and G. Cignarella

Affiliation:

Keywords: Opioid Receptor Like-1 (ORL-1), Nociceptin (orphanin FQ), Dynorphin A

Abstract: Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other diseases. This review deals with non-peptidic ligands at the ORL-1 receptor, focusing on their structural and binding properties. Agonism or antagonism evidenced from functional experiments is also commented. For some compounds, possible therapeutic applications are considered.

Cite this article as:

Barlocco D., Toma L. and Cignarella G., Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1), Mini-Reviews in Medicinal Chemistry 2001; 1 (4) . https://dx.doi.org/10.2174/1389557013406657