Pharmaceutical Target Identification by Gene Expression Analysis

Title: Pharmaceutical Target Identification by Gene Expression Analysis

Volume: 1 Issue: 2

Author(s): Micheal G. Walker

Affiliation:

Keywords: Gene Expression Analysis, CARDIOMYOPATHY-ASSOCIATED GENES, Cardiodilatin, Creatine kinase, Myoglobin, Telethonin, Titin, Troponin C

Abstract: The majority of newly-identified genes in the human genome show no significant sequence similarity to genes whose function is known, so they are not easily recognized as potential drug targets. Expression analysis is an alternative method to suggest possible functions of genes. We review statistical methods for gene expression analysis to identify potential pharmaceutical targets. Specifically, we illustrate the analysis of differential gene expression (using discriminant analysis, t-tests, and analysis of variance) and co-expression (using correlation, clustering, and chi-square). We present an example of the use of expression analysis to identify co-expressed cardiomyopathy-associated genes.

Cite this article as:

Walker G. Micheal, Pharmaceutical Target Identification by Gene Expression Analysis, Mini-Reviews in Medicinal Chemistry 2001; 1 (2) . https://dx.doi.org/10.2174/1389557013407034