Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimers Disease

Title: Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimers Disease

Volume: 1 Issue: 3

Author(s): Ana Castro and Ana Martinez

Affiliation:

Keywords: Acetylcholinesterase Inhibitors, Alzheimers Disease, Anti-Alzheimer drugs

Abstract: Recently advances in understanding the molecular basis of Alzheimers disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed.

Cite this article as:

Castro Ana and Martinez Ana, Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2001; 1 (3) . https://dx.doi.org/10.2174/1389557013406864