Peptidomimetics and Peptide Backbone Modifications

Jung-Mo      Ahn; Nicholas   A.   Boyle; Mary   T.   MacDonald; Kim   D.   Janda

doi:10.2174/1389557023405828

Abstract

The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review.

Keywords: peptidomimetics, backbone modifications, hydrophobicity of pseudopeptides, enzymatic stability, amino acids, human, immunodeficiency

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Mini-Reviews in Medicinal Chemistry

Title: Peptidomimetics and Peptide Backbone Modifications

Volume: 2 Issue: 5

Author(s): Jung-Mo Ahn, Nicholas A. Boyle, Mary T. MacDonald and Kim D. Janda

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Keywords: peptidomimetics, backbone modifications, hydrophobicity of pseudopeptides, enzymatic stability, amino acids, human, immunodeficiency

Abstract: The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review.

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Ahn Jung-Mo, Boyle A. Nicholas, MacDonald T. Mary and Janda D. Kim, Peptidomimetics and Peptide Backbone Modifications, Mini-Reviews in Medicinal Chemistry 2002; 2 (5) . https://dx.doi.org/10.2174/1389557023405828