Design, Synthesis, and Application of Peptide Secondary Structure Mimetics

Masakatsu      Eguchi; Michael      Kahn

doi:10.2174/1389557023405783

Abstract

The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years is reviewed along with the recent developments in this field.

Keywords: secondary structure mimetics, peptidomimetic approach, proteinaceous leads, tetrapeptide units, privileged template, reverseturn mimetics, solid phase synthesis

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Mini-Reviews in Medicinal Chemistry

Title: Design, Synthesis, and Application of Peptide Secondary Structure Mimetics

Volume: 2 Issue: 5

Author(s): Masakatsu Eguchi and Michael Kahn

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Keywords: secondary structure mimetics, peptidomimetic approach, proteinaceous leads, tetrapeptide units, privileged template, reverseturn mimetics, solid phase synthesis

Abstract: The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years is reviewed along with the recent developments in this field.

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Eguchi Masakatsu and Kahn Michael, Design, Synthesis, and Application of Peptide Secondary Structure Mimetics, Mini-Reviews in Medicinal Chemistry 2002; 2 (5) . https://dx.doi.org/10.2174/1389557023405783