AMPA Glutamate Receptors and Neuropathic Pain

Susana      Morales-Alcelay; Laura      Rubio; Ana      Martinez

doi:10.2174/1389557033487719

Abstract

Glutamate receptors are implicated in many actions in the central nervous system, as an excitatory amino acid, and one of the more relevant is its role in excitotoxicity. Apart from this, it also has a role as pronociceptive agent, so that antagonizing its actions could be of interest for developing new analgesic agents. Furthermore, between the analgesics agents, it is of outstanding interest the fact that there is no specific therapy against the neuropathic pain, and glutamate receptor subunits have elicited as new potential targets for this disturbance.

Keywords: neuropathic pain, allodynia, hyperalgesia, ampa, ionotropic receptor

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