The Impact of Combinatorial Methodologies on Medicinal Chemistry

Title: The Impact of Combinatorial Methodologies on Medicinal Chemistry

Volume: 4 Issue: 7

Author(s): Rosario M. Sanchez-Martin, Stifun Mittoo and Mark Bradley

Affiliation:

Keywords: Methodologies, scavengers, combinatorial chemistry

Abstract: Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.

Cite this article as:

Sanchez-Martin M. Rosario, Mittoo Stifun and Bradley Mark, The Impact of Combinatorial Methodologies on Medicinal Chemistry, Current Topics in Medicinal Chemistry 2004; 4 (7) . https://dx.doi.org/10.2174/1568026043451113