New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors

Title: New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors

Volume: 5 Issue: 6

Author(s): Dinah W. Y. Sah, Michael H. Ossipov, Anthony Rossomando, Laura Silvian and Frank Porreca

Affiliation:

Abstract: This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.

Cite this article as:

Dinah W. Y. Sah , Michael H. Ossipov , Anthony Rossomando , Laura Silvian and Frank Porreca , New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors, Current Topics in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1568026054367593