Chemistry for DOTA Peptide Labeling at Phenylalanine Residues: On the Road to Preparing Peptide Ligand Tagged Libraries

Luis   M. De   Leon-Rodriguez; Zoltan      Kovacs; Alan   D.   Sherry

doi:10.2174/1570178053202838

Abstract

Different synthetic strategies to control the position of DOTA in phenylalanine residues within a peptide sequence were studied and compared. The results showed that use of DOTA pre-labeled amino acids stands as the most promising procedure for the synthesis of peptide ligand tagged libraries by solid phase peptide synthesis.

Keywords: peptide, dota, tag, phenylalanine, mri

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Letters in Organic Chemistry

Title: Chemistry for DOTA Peptide Labeling at Phenylalanine Residues: On the Road to Preparing Peptide Ligand Tagged Libraries

Volume: 2 Issue: 2

Author(s): Luis M. De Leon-Rodriguez, Zoltan Kovacs and Alan D. Sherry

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Keywords: peptide, dota, tag, phenylalanine, mri

Abstract: Different synthetic strategies to control the position of DOTA in phenylalanine residues within a peptide sequence were studied and compared. The results showed that use of DOTA pre-labeled amino acids stands as the most promising procedure for the synthesis of peptide ligand tagged libraries by solid phase peptide synthesis.

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Leon-Rodriguez M. De Luis, Kovacs Zoltan and Sherry D. Alan, Chemistry for DOTA Peptide Labeling at Phenylalanine Residues: On the Road to Preparing Peptide Ligand Tagged Libraries, Letters in Organic Chemistry 2005; 2 (2) . https://dx.doi.org/10.2174/1570178053202838