New Derivatives of Picolinic Acid and Nicotinic Acid with Anticonvulsant Activity

Title: New Derivatives of Picolinic Acid and Nicotinic Acid with Anticonvulsant Activity

Volume: 12 Issue: 7

Author(s): Ryszard Paruszewski, Marzanna Strupinska, Grazyna Rostafinska-Suchar and James P. Stables

Affiliation:

Keywords: anticonvulsant, activity, neurotoxicity, time of action, picolinic acid, nicotinic acid

Abstract: Previously obtained Pic-BZA is a potent anticonvulsant with low neurotoxicity, but its half-time of action is only about 15 min. In search for equally effective anticonvulsants but with a longer time of action fourteen Pic-BZA analogs were obtained. The compounds were evaluated in the Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH. Picolinic acid 2-fluorobenzylamide (Pic-2-F-BZA, 7) appeared to be the most effective compound of the series.

Cite this article as:

Paruszewski Ryszard, Strupinska Marzanna, Rostafinska-Suchar Grazyna and Stables P. James, New Derivatives of Picolinic Acid and Nicotinic Acid with Anticonvulsant Activity, Protein & Peptide Letters 2005; 12 (7) . https://dx.doi.org/10.2174/0929866054696046