Cross-Metathesis: Efficient Preparation of Trialkyl-Substituted Isoprenoid Olefins as Key-Intermediates for Tocopherol Synthesis

Thomas      Netscher

doi:10.2174/156802605775009775

Abstract

A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.

Keywords: Ruthenium-catalysis, tocopherols, isoprenoids, E/Z selectivity, homo-coupling

« Previous

Rights & Permissions Print Cite

Current Topics in Medicinal Chemistry

Title: Cross-Metathesis: Efficient Preparation of Trialkyl-Substituted Isoprenoid Olefins as Key-Intermediates for Tocopherol Synthesis

Volume: 5 Issue: 15

Author(s): Thomas Netscher

Affiliation:

Keywords: Ruthenium-catalysis, tocopherols, isoprenoids, E/Z selectivity, homo-coupling

Abstract: A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Netscher Thomas, Cross-Metathesis: Efficient Preparation of Trialkyl-Substituted Isoprenoid Olefins as Key-Intermediates for Tocopherol Synthesis, Current Topics in Medicinal Chemistry 2005; 5 (15) . https://dx.doi.org/10.2174/156802605775009775