Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1

Title: Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1

Volume: 7 Issue: 15

Author(s): Maria A. Bednarek

Affiliation:

Keywords: Melanin-concentrating hormone, melanin-concentrating hormone receptor, antagonist, obesity

Abstract: The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents.

Cite this article as:

Bednarek A. Maria, Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1, Current Topics in Medicinal Chemistry 2007; 7 (15) . https://dx.doi.org/10.2174/156802607782194734