α-Fluorinated Ethers as “Exotic” Entity in Medicinal Chemistry

Title: α-Fluorinated Ethers as “Exotic” Entity in Medicinal Chemistry

Volume: 7 Issue: 10

Author(s): Peter Jeschke, Eckhard Baston and Frederic R. Leroux

Affiliation:

Keywords: Fluorine, trifluoromethoxy group, anesthetics, cardiovascular drugs, respiratory drugs, neurological drugs, gastrointestinal drugs, anti-infective therapeutics

Abstract: After nitrogen, fluorine occupies the position of second favorite heteroelement in life science-oriented research. In contrast, the trifluoromethoxy group is still perhaps the least well understood fluorine substituent, although its occurrence has significantly increased in the recent years. Today, significant application areas for trifluoromethoxy substituted pharmaceuticals are in the field of analgesics, anesthetics, cardiovascular drugs, respiratory drugs, psychopharmacologic drugs, neurological drugs, gastrointestinal drugs and anti-infective therapeutics. The present review will give an overlook of its use in medicinal chemistry.

Cite this article as:

Jeschke Peter, Baston Eckhard and Leroux R. Frederic, α-Fluorinated Ethers as “Exotic” Entity in Medicinal Chemistry, Mini-Reviews in Medicinal Chemistry 2007; 7 (10) . https://dx.doi.org/10.2174/138955707782110150