Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD)

Title: Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD)

Volume: 7 Issue: 9

Author(s): Carmen Quintana

Affiliation:

Keywords: Ferritinopathy, neuropathology, alzheimer, analytical microscopies, nanoSIMS

Abstract: Using analytical microscopies we have observed an increase of Fe2+ iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific agingdependent pathogenic event responsible for neurodegenerative disease.

Cite this article as:

Quintana Carmen, Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD), Mini-Reviews in Medicinal Chemistry 2007; 7 (9) . https://dx.doi.org/10.2174/138955707781662654