Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis

Title: Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis

Volume: 14 Issue: 4

Author(s): Andre Teixeira-Ferreira and Elias Walter Alves

Affiliation:

Keywords: Bothrops jararaca, ATP-pyrophosphatase, ATPase, ADPase, Phosphodiesterase, 5'-nucleotidase

Abstract: Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme( s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates.

Cite this article as:

Teixeira-Ferreira Andre and Walter Alves Elias, Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis, Protein & Peptide Letters 2007; 14 (4) . https://dx.doi.org/10.2174/092986607780363998