Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery

Title: Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery

Volume: 7 Issue: 2

Author(s): J. A. Gerrard, C. A. Hutton and M. A. Perugini

Affiliation:

Keywords: Protein-protein interactions, inhibitor, amyloid, HIV, drug design, small molecule-protein interaction

Abstract: Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.

Cite this article as:

Gerrard A. J., Hutton A. C. and Perugini A. M., Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery, Mini-Reviews in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/138955707779802561