Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies

Title: Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies

Volume: 6 Issue: 7

Author(s): A. M. Gerber and M. L. Vallano

Affiliation:

Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design

Abstract: NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.

Cite this article as:

Gerber M. A. and Vallano L. M., Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies, Mini-Reviews in Medicinal Chemistry 2006; 6 (7) . https://dx.doi.org/10.2174/138955706777698651