Critical Update and Emerging Trends in Imatinib Treatment for Gastrointestinal Stromal Tumor

Title: Critical Update and Emerging Trends in Imatinib Treatment for Gastrointestinal Stromal Tumor

Volume: 2 Issue: 1

Author(s): Ugo De Giorgi, Alberto Pupi, Gina Turrisi, Iolanda Montenora, Stefano Morini, Mozghan Fayyaz, Michele De Simone and Giammaria Fiorentini

Affiliation:

Keywords: Imatinib, KIT, Gastrointestinal stromal tumor, GIST, Imaging

Abstract: The extraordinary success of imatinib in gastrointestinal stromal tumor (GIST) represents a model for molecularly targeted therapy of solid tumors. Research is currently going to identify the molecular basis of mechanisms of action and drug resistance. For the optimal management of the patients treated, a multidisciplinary approach, including medical oncologists, surgeons, pathologists, and radiologists is needed. In this article, we reviewed recent advances in the clinical management of GIST patients treated with imatinib, and in the knowledge of the molecular mechanisms that are basic to imatinib effects.

Cite this article as:

De Giorgi Ugo, Pupi Alberto, Turrisi Gina, Montenora Iolanda, Morini Stefano, Fayyaz Mozghan, De Simone Michele and Fiorentini Giammaria, Critical Update and Emerging Trends in Imatinib Treatment for Gastrointestinal Stromal Tumor, Reviews on Recent Clinical Trials 2007; 2 (1) . https://dx.doi.org/10.2174/157488707779318143