Residues Around the Catalytic Pocket of DdsA Are Important for Isoprenoids Chain Elongation

Xinyi      Liu; Qinsheng      Yuan; Huizhan      Zhang

doi:10.2174/092986607779117245

Abstract

Nineteen mutants of decaprenyl diphosphate synthase from Gluconobacter suboxydans were generated and their production of ubiquinones (UQs) was compared to that of the wild type protein. The accessible surface area and the polarity of amino acid around the catalytic pocket wield remarkable influences on the isoprenoid chain elongation of UQs.

Keywords: Decaprenyl diphosphate synthase, ubiquinone, site-directed mutagenesis

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Protein & Peptide Letters

Title: Residues Around the Catalytic Pocket of DdsA Are Important for Isoprenoids Chain Elongation

Volume: 14 Issue: 1

Author(s): Xinyi Liu, Qinsheng Yuan and Huizhan Zhang

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Keywords: Decaprenyl diphosphate synthase, ubiquinone, site-directed mutagenesis

Abstract: Nineteen mutants of decaprenyl diphosphate synthase from Gluconobacter suboxydans were generated and their production of ubiquinones (UQs) was compared to that of the wild type protein. The accessible surface area and the polarity of amino acid around the catalytic pocket wield remarkable influences on the isoprenoid chain elongation of UQs.

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Liu Xinyi, Yuan Qinsheng and Zhang Huizhan, Residues Around the Catalytic Pocket of DdsA Are Important for Isoprenoids Chain Elongation, Protein & Peptide Letters 2007; 14 (1) . https://dx.doi.org/10.2174/092986607779117245