New Insights into the Regulation of Liver Inflammation and Oxidative Stress

Title: New Insights into the Regulation of Liver Inflammation and Oxidative Stress

Volume: 6 Issue: 12

Author(s): Natalia Ferre and Joan Claria

Affiliation:

Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species

Abstract: Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.

Cite this article as:

Ferre Natalia and Claria Joan, New Insights into the Regulation of Liver Inflammation and Oxidative Stress, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778993049