Silicon Switches of Marketed Drugs

Title: Silicon Switches of Marketed Drugs

Volume: 6 Issue: 10

Author(s): P. K. Pooni and G. A. Showell

Affiliation:

Keywords: Organosilicon chemistry, silicon switch, marketed drugs, validated targets

Abstract: The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.

Cite this article as:

K. Pooni P. and A. Showell G., Silicon Switches of Marketed Drugs, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560120