Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease

Title: Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease

Volume: 6 Issue: 10

Author(s): Yasumasa Ohyagi and Takeshi Tabira

Affiliation:

Keywords: Alzheimer's disease, amyloid β-protein, intracellular, intranuclear, Aβ-related Death Inducing Protein, p53, promoter, apoptosis, amyloid -protein, related Death Inducing Protein

Abstract: Amyloid β-protein (Aβ) plays a pivotal role in Alzheimers disease (AD). Therapeutic strategies inhibiting Aβ aggregation and promoting extracellular Aβ removal are currently advocated. Here, we review recent literature on intracellular Aβ, especially intranuclear Aβ, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Aβ-related pathogenesis.

Cite this article as:

Ohyagi Yasumasa and Tabira Takeshi, Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560175