Versatile Synthesis of MRI Contrast Agents Based on Carbon-Substituted Triazacycloalkanes

Lassi      Jaakkola; Jari      Hovinen

doi:10.2174/157017806778559491

Abstract

3-(4-Iodophenoxy)-tris(2-nitrobenzenesulfonyl)-1,4,7-triazacyclodecane (5a) was synthesized by a Mitsunobu reaction between pernosylated diethylenetriamine (4a) and 1,3-bis(trityloxy)propan-2-ol (2). 5a served as a key intermediate in the preparation of MRI contrast agents allowing biomolecule labeling both in solution and on solid phase.

Keywords: MRI, labeling, azamacrocycle, Mitsunobu reaction

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Letters in Organic Chemistry

Title: Versatile Synthesis of MRI Contrast Agents Based on Carbon-Substituted Triazacycloalkanes

Volume: 3 Issue: 8

Author(s): Lassi Jaakkola and Jari Hovinen

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Keywords: MRI, labeling, azamacrocycle, Mitsunobu reaction

Abstract: 3-(4-Iodophenoxy)-tris(2-nitrobenzenesulfonyl)-1,4,7-triazacyclodecane (5a) was synthesized by a Mitsunobu reaction between pernosylated diethylenetriamine (4a) and 1,3-bis(trityloxy)propan-2-ol (2). 5a served as a key intermediate in the preparation of MRI contrast agents allowing biomolecule labeling both in solution and on solid phase.

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Jaakkola Lassi and Hovinen Jari, Versatile Synthesis of MRI Contrast Agents Based on Carbon-Substituted Triazacycloalkanes, Letters in Organic Chemistry 2006; 3 (8) . https://dx.doi.org/10.2174/157017806778559491