A Practical Synthesis of Thio-Bisphosphonic Acids For the Treatment of Arthritis, Based on the Chemistry of Tetraethyl Methylene-1,1- Bisphosphonate

Wafaa   M.   Abdou; Maha   D.   Khidre; Ashraf   A.   Sediek

doi:10.2174/157017806778559536

Abstract

The synthesis of novel S-bisphosphonates (S-BPs) by two different approaches is described. Hydrolysis of the resulted BPs with conc. HCl afforded the corresponding thio-bisphosphonic acids. The properties of these compounds in the rat adjuvant model of arthritis, and the synthetic routes to these and related compounds are detailed.

Keywords: Cyclic-and acyclic cis-disulfides, Shiff-bases, Sulfur-containing bisphosphonic acids, Arthritis/Inflammatory

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Letters in Organic Chemistry

Title: A Practical Synthesis of Thio-Bisphosphonic Acids For the Treatment of Arthritis, Based on the Chemistry of Tetraethyl Methylene-1,1- Bisphosphonate

Volume: 3 Issue: 8

Author(s): Wafaa M. Abdou, Maha D. Khidre and Ashraf A. Sediek

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Keywords: Cyclic-and acyclic cis-disulfides, Shiff-bases, Sulfur-containing bisphosphonic acids, Arthritis/Inflammatory

Abstract: The synthesis of novel S-bisphosphonates (S-BPs) by two different approaches is described. Hydrolysis of the resulted BPs with conc. HCl afforded the corresponding thio-bisphosphonic acids. The properties of these compounds in the rat adjuvant model of arthritis, and the synthetic routes to these and related compounds are detailed.

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Abdou M. Wafaa, Khidre D. Maha and Sediek A. Ashraf, A Practical Synthesis of Thio-Bisphosphonic Acids For the Treatment of Arthritis, Based on the Chemistry of Tetraethyl Methylene-1,1- Bisphosphonate, Letters in Organic Chemistry 2006; 3 (8) . https://dx.doi.org/10.2174/157017806778559536