The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases

Title: The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases

Volume: 6 Issue: 9

Author(s): Hirokazu Tamamura, Hiroshi Tsutsumi and Nobutaka Fujii

Affiliation:

Keywords: Leukemia cell progression, cancer metastasis, chemokine receptor, HIV infection, low molecular weight CXCR4 antagonist, rheumatoid arthritis, T140, T22

Abstract: CXCR4 is the receptor for a chemokine, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12- CXCR4 axis has been proven to be involved in several problematic diseases, including AIDS, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis (RA). Thus, CXCR4 is thought to be an important therapeutic target to overcome the above diseases. We have developed several specific CXCR4 antagonists.

Cite this article as:

Tamamura Hirokazu, Tsutsumi Hiroshi and Fujii Nobutaka, The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases, Mini-Reviews in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/138955706778195135