Hydrophilic Carotenoid Amphiphiles: Methods of Synthesis and Biological Applications

Title: Hydrophilic Carotenoid Amphiphiles: Methods of Synthesis and Biological Applications

Volume: 6 Issue: 9

Author(s): Bente Jeanette Foss, Geoff Nadolski and Samuel F. Lockwood

Affiliation:

Keywords: Aggregation, antioxidants, carotenoids, hydrophilic carotenoids, reactive oxygen species (ROS), retrometabolic drug design, soft drugs, tissue tropism

Abstract: Carotenoid bioactivity, namely the quenching of reactive oxygen species (ROS) and other excited-state oxidants, suggests significant clinical potential for these natural products. However, a thorough therapeutic evaluation of the carotenoids has been hampered by limited water-solubility and/or water-dispersibility (“hydrophilicity”) as well as poor bioavailability. Hydrophilic carotenoid derivatives have been designed and prepared for parenteral administration. Synthetic methods, selected physical characteristics, and potential biological applications of these novel therapeutics will be discussed.

Cite this article as:

Jeanette Foss Bente, Nadolski Geoff and Lockwood F. Samuel, Hydrophilic Carotenoid Amphiphiles: Methods of Synthesis and Biological Applications, Mini-Reviews in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/138955706778195225