Abstract
β-Amino alcohols possessing an alkynyl functionality were converted into bicyclic compounds via a 5-exo-dig radical cyclization. One of this bicyclic product was transformed in three steps into the (2R,3S,5S)- 3-methyl-5-iso-propyl proline.
Keywords: Amino alcohols, radical cyclization, proline derivative
Letters in Organic Chemistry
Title: A Radical Route to a cis-3,5-Dialkyl Proline Derivative
Volume: 3 Issue: 4
Author(s): Sebastien Guesne, Sebastien Comesse and Catherine Kadouri-Puchot
Affiliation:
Keywords: Amino alcohols, radical cyclization, proline derivative
Abstract: β-Amino alcohols possessing an alkynyl functionality were converted into bicyclic compounds via a 5-exo-dig radical cyclization. One of this bicyclic product was transformed in three steps into the (2R,3S,5S)- 3-methyl-5-iso-propyl proline.
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Cite this article as:
Guesne Sebastien, Comesse Sebastien and Kadouri-Puchot Catherine, A Radical Route to a cis-3,5-Dialkyl Proline Derivative, Letters in Organic Chemistry 2006; 3 (4) . https://dx.doi.org/10.2174/157017806776114667
DOI https://dx.doi.org/10.2174/157017806776114667 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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