Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Aromatic Amines Catalyzed by Tin (II) Chloride [1]

Srinivas   R.   Adapa; Ramu      Enugala; M.   M.   A.; Ravi      Varala

doi:10.2174/157017806775789930

Abstract

Tin (II) chloride dihydrate catalyses the nucleophilic ring opening of epoxide by aromatic amines leading to an efficient synthesis of β-amino alcohols in very good yields. The reactions are completely antistereoselective, highly regioselctive and proceed at ambient temperature which make this procedure particularly an alternative strategy for the synthesis of β-amino alcohols.

Keywords: β-amino alcohols, tin (II) chloride dihydrate (SnCl2.2H2O), aromatic amines, Epoxides

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Letters in Organic Chemistry

Title: Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Aromatic Amines Catalyzed by Tin (II) Chloride [1]

Volume: 3 Issue: 3

Author(s): Srinivas R. Adapa, Ramu Enugala, M. M. A. and Ravi Varala

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Keywords: β-amino alcohols, tin (II) chloride dihydrate (SnCl2.2H2O), aromatic amines, Epoxides

Abstract: Tin (II) chloride dihydrate catalyses the nucleophilic ring opening of epoxide by aromatic amines leading to an efficient synthesis of β-amino alcohols in very good yields. The reactions are completely antistereoselective, highly regioselctive and proceed at ambient temperature which make this procedure particularly an alternative strategy for the synthesis of β-amino alcohols.

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Adapa R. Srinivas, Enugala Ramu, A. M. M. and Varala Ravi, Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Aromatic Amines Catalyzed by Tin (II) Chloride [1], Letters in Organic Chemistry 2006; 3 (3) . https://dx.doi.org/10.2174/157017806775789930