Green Route to the 2,6-Disubstituted Imidazo[2,1-b]-1,3,4-Thiadiazoles by the Cyclocondensation of α-Bromoacetophenone Derivative and 1,3,4- Thiadiazoles Using Ionic Liquids

Mazaahir      Kidwai; Shweta      Rastogi

doi:10.2174/157017806775224233

Abstract

An eco-friendly facile synthesis of imidazo[2,1-b]-1,3,4-thiadiazoles is described using ionic liquid, [bmim]PF6 (1-butyl-3-methylimidazolium hexafluorophosphate). The use of recyclable catalyst demonstrates the advantages of significant rate enhancement along with improved yields. The protocol is green and effective for producing the desired target moiety.

Keywords: Thiadiazole, ionic liquid, a-bromoacetophenone, imidazo[2,1-b]-1,3,4-, thiadiazoles

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Letters in Organic Chemistry

Title: Green Route to the 2,6-Disubstituted Imidazo[2,1-b]-1,3,4-Thiadiazoles by the Cyclocondensation of α-Bromoacetophenone Derivative and 1,3,4- Thiadiazoles Using Ionic Liquids

Volume: 3 Issue: 2

Author(s): Mazaahir Kidwai and Shweta Rastogi

Affiliation:

Keywords: Thiadiazole, ionic liquid, a-bromoacetophenone, imidazo[2,1-b]-1,3,4-, thiadiazoles

Abstract: An eco-friendly facile synthesis of imidazo[2,1-b]-1,3,4-thiadiazoles is described using ionic liquid, [bmim]PF6 (1-butyl-3-methylimidazolium hexafluorophosphate). The use of recyclable catalyst demonstrates the advantages of significant rate enhancement along with improved yields. The protocol is green and effective for producing the desired target moiety.

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Kidwai Mazaahir and Rastogi Shweta, Green Route to the 2,6-Disubstituted Imidazo[2,1-b]-1,3,4-Thiadiazoles by the Cyclocondensation of α-Bromoacetophenone Derivative and 1,3,4- Thiadiazoles Using Ionic Liquids, Letters in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157017806775224233