The Natural Amino Acid Derived Chiral Sulfonamide Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes

Title: The Natural Amino Acid Derived Chiral Sulfonamide Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes

Volume: 3 Issue: 2

Author(s): Zhi-jian Han, Chao-shan Da, Li Qiu, Ming Ni, Yi-feng Zhou and Rui Wang

Affiliation:

Keywords: Sulfonamide alcohol, asymmetric addition, phenylacetylene, aldehyde

Abstract: Several simple amino acids derived chiral sulfonamide ligands were synthesized in simple three steps. When we used these ligands in the asymmetric addition of phenylacetylene to aldehydes, the corresponding propargylic alcohols were isolated with good yields. The highest ee value was obtained up to 99%. The results proved that the backbone of the chiral source greatly influenced the enantioselectivity.

Cite this article as:

Han Zhi-jian, Da Chao-shan, Qiu Li, Ni Ming, Zhou Yi-feng and Wang Rui, The Natural Amino Acid Derived Chiral Sulfonamide Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes, Letters in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157017806775224161