Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional Cancer Therapies

Bettina      M. Kaminski; Dieter      Steinhilber; Jurgen      M. Stein; Sandra      Ulrich

doi:10.2174/138920112798868746

Abstract

Even though conventional cancer therapies, comprising surgery and chemo- and radiotherapy, play an important role in the treatment of most solid tumours, successful therapeutic outcome is often limited due to high toxicity and related side-effects, as well as the development of multi-drug resistances. Therefore, there is need for new therapeutic strategies not only to obtain higher treatment efficacy, but also for the reduction of toxicity and adverse effects. Emerging evidence suggests that natural compounds with distinct anticarcinogenic activity may be considered as potential agents for enhancing the therapeutic effects of common cancer treatments. By using the examples of resveratrol and sulforaphane this review will summarize the findings of recent investigations focusing this topic so far and the current knowledge of the molecular mechanisms by which these selected phytochemicals may potentiate the anti-tumor effects of different cancer therapies.

Keywords: Cancer treatment, chemosensitizers, phytochemicals, resveratrol, sulforaphane, chemo- and radiotherapy, toxicity, multi-drug resistances, higher treatment efficacy, anticarcinogenic activity, multi-drug resistance, chemosensitizing activities