Artificial Enzymes: A Review

Vandana      Sharma; Mukesh      Bachwani

doi:10.2174/157340811798807623

Abstract

Enzymes are truly outstanding biological catalysts with the ability to accelerate the rate of chemical reactions up to 1019 times for specific substrates and reactions. New approaches based on amino acids or peptides as characteristic molecular moieties have led to a significant expansion of the field of artificial enzymes or enzyme mimics, catalyzing various reactions with rate increases up to 103. A number of possibilities now exist for the construction of artificial enzymes. These are generally synthetic polymers or oligomers with enzyme-like activities, often called synzymes. This review has basic information about Ideal Requirement for Artificial Enzymes Environment, Design Approach for Artificial Enzyme and their Significance for further development in this field.

Keywords: Artificial enzymes, synzyme, enzyme mimics, chemzymes, star polymers, catalysts, metalloproteins, peptides, de novo design, chirality