Ox-LDL Particles: Modified Components, Cellular Uptake, Biological Roles and Clinical Assessments

Title: Ox-LDL Particles: Modified Components, Cellular Uptake, Biological Roles and Clinical Assessments

Volume: 11 Issue: 2

Author(s): Mohammad Najafi, Abazar Roustazadeh and Behnam Alipoor

Affiliation:

Keywords: Ox-LDL, Components, Scavenger receptors, Blocks, Cardiovascular disease, Lysophosphatidylcholine, sn-2 acyl group, PAF-AH enzymes, chain-oxidized oxysterols, malondialdehyde

Abstract: Among concepts proposed to elucidate atherosclerosis process, the oxidative modification hypothesis is more considered to be investigated in studies. Based on the hypothesis, the LDL components are chemically modified due to oxidative stress within subendothelial space of vessels. The cells are able to recognize the oxidized LDL (ox-LDL) preparations so that inflammatory events spread through intracellular pathways and lead to the cellular dysfunction and the production of atherosclerotic plaques. The circulating ox-LDL level is suggested as biomarker of atherogenic lesions. However, it is not confirmed in some studies since the circulating ox-LDL clearance during the extent of atherosclerosis process is related to function of scavenger receptors and the serum anti LDL levels. The report is focused on the biochemical characteristics of modified LDL components, the cellular internalization of ox-LDL particles through the scavenger receptors, prediction of consensus blocks in the receptor sequences and the circulating ox-LDL assessments in cardiovascular complications.

Cite this article as:

Najafi Mohammad, Roustazadeh Abazar and Alipoor Behnam, Ox-LDL Particles: Modified Components, Cellular Uptake, Biological Roles and Clinical Assessments, Cardiovascular & Hematological Disorders-Drug Targets 2011; 11 (2) . https://dx.doi.org/10.2174/187152911798346990