Design and Synthesis of Novel Chemokine Analogs Derived from vMIP-II

Jun      Wang; Santhosh      Kumar; Won-Tak      Choi; Changzhi      Dong; Ziwei      Huang

doi:10.2174/092986606776819574

Abstract

Stepwise solid phase synthesis using the Fmoc chemistry is reported for a panel of 71-residue and novel unnatural chemokine analogs derived from vMIP-II. This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors.

Keywords: Chemical Synthesis, SPPS (Solid Phase Peptide Synthesis), Chemokine, vMIP-II

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Protein & Peptide Letters

Title: Design and Synthesis of Novel Chemokine Analogs Derived from vMIP-II

Volume: 13 Issue: 5

Author(s): Jun Wang, Santhosh Kumar, Won-Tak Choi, Changzhi Dong and Ziwei Huang

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Keywords: Chemical Synthesis, SPPS (Solid Phase Peptide Synthesis), Chemokine, vMIP-II

Abstract: Stepwise solid phase synthesis using the Fmoc chemistry is reported for a panel of 71-residue and novel unnatural chemokine analogs derived from vMIP-II. This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors.

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Wang Jun, Kumar Santhosh, Choi Won-Tak, Dong Changzhi and Huang Ziwei, Design and Synthesis of Novel Chemokine Analogs Derived from vMIP-II, Protein & Peptide Letters 2006; 13 (5) . https://dx.doi.org/10.2174/092986606776819574