Synthesis of Peptidyl Ureas Employing O-succinimidyl-(9H-fluoren-9- ylmethoxycarbonylamino)methylcarbamate Derivatives as Activated Monomers

Vommina   V.   Sureshbabu; Naremaddepalli   S.   Sudarshan; Gundala   C.   Krishna

doi:10.2174/092986606776819556

Abstract

A convenient and efficient method for the synthesis of dipeptidyl ureas and urea acids employing Osuccinimidyl-( 9H-fluoren-9-ylmethoxycarbonyl amino)methylcarbamates has been described. All the compounds, obtained in good yields, have been fully characterized by mass and NMR spectra.

Keywords: dichloromethane (DCM), Dipeptidyl Urea Acids, NMR, protease, Schotten-Baumann conditions

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Protein & Peptide Letters

Title: Synthesis of Peptidyl Ureas Employing O-succinimidyl-(9H-fluoren-9- ylmethoxycarbonylamino)methylcarbamate Derivatives as Activated Monomers

Volume: 13 Issue: 5

Author(s): Vommina V. Sureshbabu, Naremaddepalli S. Sudarshan and Gundala C. Krishna

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Keywords: dichloromethane (DCM), Dipeptidyl Urea Acids, NMR, protease, Schotten-Baumann conditions

Abstract: A convenient and efficient method for the synthesis of dipeptidyl ureas and urea acids employing Osuccinimidyl-( 9H-fluoren-9-ylmethoxycarbonyl amino)methylcarbamates has been described. All the compounds, obtained in good yields, have been fully characterized by mass and NMR spectra.

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Sureshbabu V. Vommina, Sudarshan S. Naremaddepalli and Krishna C. Gundala, Synthesis of Peptidyl Ureas Employing O-succinimidyl-(9H-fluoren-9- ylmethoxycarbonylamino)methylcarbamate Derivatives as Activated Monomers, Protein & Peptide Letters 2006; 13 (5) . https://dx.doi.org/10.2174/092986606776819556