Ether Lipids as Anticancer Agents: Focus on Non-Phosphorus Cationic Glycerolipids

Title: Ether Lipids as Anticancer Agents: Focus on Non-Phosphorus Cationic Glycerolipids

Volume: 6 Issue: 5

Author(s): N. V. Plyavnik, A. A. Shtil and G. A. Serebrennikova

Affiliation:

Keywords: Ether lipids, Non-phosphorus cationic glycerolipids, Anticancer drugs, Edelfosine (ET-18-OMe)

Abstract: This review focuses on the synthesis and mechanisms of antitumor activity of cationic nonphosphorus analogs of edelfosine. The role of variable length and mode of conjugation of the spacer group, the types of cationic head, and the length of the substituent at C(2) atom of the glycerol backbone are discussed, providing the basis for rational design of lipophilic anticancer drugs, in particular, for elimination of multidrug resistant cells.

Cite this article as:

Plyavnik V. N., Shtil A. A. and Serebrennikova A. G., Ether Lipids as Anticancer Agents: Focus on Non-Phosphorus Cationic Glycerolipids, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876221