Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins

Title: Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins

Volume: 11 Issue: 2

Author(s): Jonathan F. Arambula, Christian Preihs, Derric Borthwick, Darren Magda and Jonathan L. Sessler

Affiliation:

Keywords: Texaphyrin, reactive oxygen species, anticancer activity, mechanism of action, zinc, platinum delivery, alpha and beta core emitters, superoxide dismutase, amyotrophic lateral sclerosis (ALS), Parkinson's Disease (PD), Alzheimer's Disease (AD), hydroquinones, chronic lymphocytic leukemia (CLL), Gd-oxalate-Gd bridging interactions, NAD levels

Abstract: Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimentaluse in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.

Cite this article as:

F. Arambula Jonathan, Preihs Christian, Borthwick Derric, Magda Darren and L. Sessler Jonathan, Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (2) . https://dx.doi.org/10.2174/187152011795255894