Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma

Title: Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma

Volume: 6 Issue: 3

Author(s): Reinoud Gosens, Dedmer Schaafsma, S. A. Nelemans and Andrew J. Halayko

Affiliation:

Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil

Abstract: In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.

Cite this article as:

Gosens Reinoud, Schaafsma Dedmer, Nelemans A. S. and Halayko J. Andrew, Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073402