Abstract
Biotransfomation has been increasingly utilized as a tool to generate pharmaceutical lead compounds from natural products in recent years. A wide variety of natural pruducts including aromatics, steroids, alkaloids, coumarins, flavonoids and terpenoids can be biotransformed by fungi, yeasts, bacteria, plant cells and enzymes derived from these sources. The biochemical reactions occurring in microorganisms and plant cells are typically regio- and stereo-selective, which is difficult to be achieved by chemical methods. In this review we describe important biotransformations used for the generation of lead compounds with pharmaceutical utilities and further structural diversification of complex natural products, especially those from traditional Chinese medicines. Such approach will ultimately benefit the advancement of biotransformation and potential therapeutics.
Keywords: Biotransformation, Natural product, Bioactive compound, Enzyme catalysis, Drug discovery, Terpenoids, Alkaloids, Steroids
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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