Abstract
Monoclonal antibodies capable of recognizing antigens with high affinity and specificity represent a wellestablished class of biological agents. Since the development of hybridoma technology in 1975, advances in recombinant DNA technologies and computational and biophysical methods have allowed us to develop a better understanding of the relationships between antibody sequence, structure, and function. These advances enable us to manipulate antibody sequences with the goal of improving upon, or creating new biological or biophysical properties. In this review we will focus on recent successes in using structure-guided computational methods to design antibodies and antibody-like molecules with optimized affinity and specificity to antigen and for enhancing protein stability.
Keywords: Antibody engineering, structure-based design, affinity maturation, effector function, protein stability
Current Computer-Aided Drug Design
Title: Structure-Guided Design of Antibodies
Volume: 6 Issue: 2
Author(s): Justin A. Caravella, Deping Wang, Scott M. Glaser and Alexey Lugovskoy
Affiliation:
Keywords: Antibody engineering, structure-based design, affinity maturation, effector function, protein stability
Abstract: Monoclonal antibodies capable of recognizing antigens with high affinity and specificity represent a wellestablished class of biological agents. Since the development of hybridoma technology in 1975, advances in recombinant DNA technologies and computational and biophysical methods have allowed us to develop a better understanding of the relationships between antibody sequence, structure, and function. These advances enable us to manipulate antibody sequences with the goal of improving upon, or creating new biological or biophysical properties. In this review we will focus on recent successes in using structure-guided computational methods to design antibodies and antibody-like molecules with optimized affinity and specificity to antigen and for enhancing protein stability.
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Cite this article as:
A. Caravella Justin, Wang Deping, M. Glaser Scott and Lugovskoy Alexey, Structure-Guided Design of Antibodies, Current Computer-Aided Drug Design 2010; 6 (2) . https://dx.doi.org/10.2174/157340910791202469
DOI https://dx.doi.org/10.2174/157340910791202469 |
Print ISSN 1573-4099 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6697 |
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