Abstract
Cell-penetrating peptides (CPP), also called protein transduction domains (PTD), membrane-permeable peptides (MPP), or Trojan horse peptides, have been used in many different research areas. The delivery of heat shock proteins (Hsp) using CPP has been applied in models for apoptosis, necrosis, oxidative stress, neurodegenerative diseases, stroke, cystic fibrosis, smooth muscle relaxation, myocardial injury, scar formation, and others. This review summarizes the accomplishments of the field over the last years and discusses why Hsp are particularly suitable for CPP-mediated delivery.
Keywords: Protein delivery, Trojan horse, HIV-Tat, Antennapedia (Penetratin), arginine-rich peptide, Ischemia, stroke, Pep-1
Current Pharmaceutical Biotechnology
Title: Cell-Penetrating Peptide Technology to Deliver Chaperones and Associated Factors in Diseases and Basic Research
Volume: 11 Issue: 2
Author(s): Gunnar P.H. Dietz
Affiliation:
Keywords: Protein delivery, Trojan horse, HIV-Tat, Antennapedia (Penetratin), arginine-rich peptide, Ischemia, stroke, Pep-1
Abstract: Cell-penetrating peptides (CPP), also called protein transduction domains (PTD), membrane-permeable peptides (MPP), or Trojan horse peptides, have been used in many different research areas. The delivery of heat shock proteins (Hsp) using CPP has been applied in models for apoptosis, necrosis, oxidative stress, neurodegenerative diseases, stroke, cystic fibrosis, smooth muscle relaxation, myocardial injury, scar formation, and others. This review summarizes the accomplishments of the field over the last years and discusses why Hsp are particularly suitable for CPP-mediated delivery.
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Cite this article as:
Dietz P.H. Gunnar, Cell-Penetrating Peptide Technology to Deliver Chaperones and Associated Factors in Diseases and Basic Research, Current Pharmaceutical Biotechnology 2010; 11 (2) . https://dx.doi.org/10.2174/138920110790909731
DOI https://dx.doi.org/10.2174/138920110790909731 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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