Abstract
In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators.
Keywords: Cancer, Epigenetic inhibitors, Histone deacetylase, Immunotherapy, Malignant pleural mesothelioma.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Volume: 16 Issue: 7
Author(s): Malik Hamaidia, Bernard Staumont, Bernard Duysinx, Renaud Louis and Luc Willems
Affiliation:
Keywords: Cancer, Epigenetic inhibitors, Histone deacetylase, Immunotherapy, Malignant pleural mesothelioma.
Abstract: In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators.
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Hamaidia Malik, Staumont Bernard, Duysinx Bernard, Louis Renaud and Willems Luc, Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators, Current Topics in Medicinal Chemistry 2016; 16 (7) . https://dx.doi.org/10.2174/1568026615666150825141152
DOI https://dx.doi.org/10.2174/1568026615666150825141152 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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