Biological Activity of Cytokines: An Evolutionary Perspective

Title: Biological Activity of Cytokines: An Evolutionary Perspective

Volume: 12 Issue: 24

Author(s): G. Scapigliati, F. Buonocore and M. Mazzini

Affiliation:

Keywords: Cytokine, Bioactivity, Evolution, Fish immunology, Teleost, IL-1

Abstract: It appears evident that teleost fish are at present the vertebrate group in which, excluding mammals, most information on the immune system is available. However, despite the great impetus on the discovery of genes homologous to mammalian immunomodulatory molecules, the knowledge on biological activities exerted by cytokines is meager. This review reports the present knowledge on the biological activities of cytokine-like and cytokines in invertebrates and coldblooded vertebrates.

Cite this article as:

Scapigliati G., Buonocore F. and Mazzini M., Biological Activity of Cytokines: An Evolutionary Perspective, Current Pharmaceutical Design 2006; 12 (24) . https://dx.doi.org/10.2174/138161206777947489