Genome-Wide Association Studies of Family Data in Pharmacogenetics: A Case Study

Title: Genome-Wide Association Studies of Family Data in Pharmacogenetics: A Case Study

Volume: 15 Issue: 32

Author(s): Amy Murphy, Jessica Lasky-Su, Kelan G. Tantisira, Augusto A. Litonjua, Christoph Lange and Scott T. Weiss

Affiliation:

Abstract: Genome-wide associations studies (GWAS) have become routine in human genetics research; however the application of GWAS to pharmacogenomics research is just beginning. As these studies make their way into pharmacogenetics, there are several considerations specific to pharmacogenetics that should be made. In this manuscript, we discuss these considerations and provide concrete examples with GWAS data for an asthma clinical trial using parentoffspring trios.

Cite this article as:

Murphy Amy, Lasky-Su Jessica, Tantisira G. Kelan, Litonjua A. Augusto, Lange Christoph and Weiss T. Scott, Genome-Wide Association Studies of Family Data in Pharmacogenetics: A Case Study, Current Pharmaceutical Design 2009; 15 (32) . https://dx.doi.org/10.2174/138161209789649493