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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Research Article

Antibacterial effect of Aloe Vera on Bacteria Isolated from Cases of Wound Infection

In Press, (this is not the final "Version of Record"). Available online 28 June, 2024
Author(s): Vaishnavi Vishram Naik, Pooja Rao, Ethel Suman and Udayalaxmi Jeppu*
Published on: 28 June, 2024

Article ID: e280624231439

DOI: 10.2174/0118715265301138240605071106

Price: $95

Abstract

Background: Antimicrobial resistance exhibited by bacteria against the major-ity of antibiotics has resulted in research on alternative methods of treatment. Aloe vera has a strong tradition as a medical plant with a wide range of therapeutic uses.

Objective: The objective of this study is to determine the antibacterial activity of gel and crude ethanol leaf extract of Aloe vera against Staphylococcus aureus and Enterobacter-ales isolated from wound infections.

Methods: It is a cross-sectional study conducted over a period of 7 months. Antibacterial effect of the ethanol leaf extract and gel was determined by the punch well method. Min-imum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the ethanol leaf extract were determined by macro broth dilution technique.

Results: Aloe vera ethanol leaf extract induced a mean zone size of 13.0 ± 6.0 mm and 16.7 ± 8.4 mm, respectively, for S. aureus and Enterobacterales by Punch Well method (p≤0.002). Whereas Aloe vera gel failed to induce any zone of inhibition for all the isolates p<0.001. Mean MIC of Aloe vera leaf extract against 74 S. aureus was 94 ± 41.23 mg/ml and against 73 Enterobacterales, it was 45.6 ± 20 mg/ml p < 0.001. Mean MBC of Aloe vera leaf extract against 74 S.aureus isolates was 188 ± 82.46 mg/ml and against 73 En-terobacterales was 91.18±40 mg/ml p < 0.001.

Conclusion: Aloe vera ethanol leaf extract showed a good antibacterial effect against the different strains of bacteria causing wound infection. The present article shows the possi-bility of future use of natural products for the treatment of wound infections.

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